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The Stockholm Convention established a science-based process for new persistent organic pollutants (POPs) under the Stockholm Convention. The Convention recognizes that a lack of full scientific certainty should not prevent a candidate substance from proceeding in the evaluation or listing and clearly mandates Parties to decide on listing “in a precautionary manner.” This new Guide highlights three new candidates for listing in the Convention in 2017 - decabromodiphenyl ether (DecaBDE), short-chain chlorinated paraffins (SCCPs), and hexachlorobutadiene (HCBD) - and provides the POPs Review Committee's recommendation for which annex the POPs should be listed under in the Convention, the chemicals' uses, alternatives, adverse effects, and more.